米奇（比利·克里斯托BillyCrystal饰）是一名铁腕篮球裁判，他深深的热爱着自己的工作。一场意外让米奇结识了名为艾伦（德博拉·温格DebraWinger饰）的美丽异国女子，很快，米奇就发现自己无法忘记艾伦的容颜，当他千里迢迢重返法国企图找到艾伦时，才发现艾伦已经结婚了ddd　　失落的米奇回到了美国，情绪陷入了低谷之中，让他没有想到的是，某日，艾伦竟然出现在了他的面前，甚至为了他辞去了她在法国的职务，就这样，米奇和艾伦开始了共同的生活。然而，生活中的各种摩擦让米奇和艾伦争吵不断，而为了安慰和陪伴艾伦，米奇毅然决定放弃自己心爱的职业，成为了一名销售员。米奇和艾伦都觉得，或许一个孩子的降生能够挽回两人之间伤痕累累的感情，可是直到这时两人才发现，艾伦根本就无法生育。

　　NovelistLarryDonner(BillyCrystal)struggleswithwriter'sblockduetohisresentmenttowardshisex-wifeMargaret(KateMulgrew),whostolehisbookandgarneredmainstreamsuccessandcriticalacclaimwithit.OwenLift(DannyDeVito)isatimid,middle-agedmanwhostillliveswithhisoverbearing,abusivemother(AnneRamsey).Owenfantasizesofkillinghismotherbutcan'tsummonthecouragetobringhisdesiresintofruition.AsastudentinLarry'scommunitycollegewritingclass,OwenisgivenadvicebyLarrytoviewanAlfredHitchcockfilmtogainsomeinsightintoplotdevelopment.HeseesStrangersonaTrain,inwhichtwostrangersconspiretocommitamurderforeachother,figuringtheirlackofconnectiontothevictimwill,intheory,establishaperfectalibi.HavingoverheardLarry'spublicrantthathewishhisex-wifedead,OwenformsaplantokillMargaret,believingthatLarrywillrespondbykillinghismotherccc　　HetracksMargaretdowntoHawaiiandfollowsherontoacruiseship,apparentlypushingheroverboardwhileshetriestoretrieveanearringthatfellout.OwenreturnsfromHawaiitotellLarryofMargaret'sdeathandthatLarrynow"owes"himthemurderofhismother,lestheinformthepoliceLarrywasthekiller.AfterhavingspentthenightdrinkingaloneduringthehoursofMargaret'sdisappearance,Larrypanicsbecausehelacksasufficientalibi.That,alongwithanewsreportannouncingthepolicesuspectfoulplay,convincesLarryhe'stheprimesuspect.HedecidestostaywithOwenandhismotherinanattempttohidefromthepolice.LarrymeetsMrs.Lift,butdespiteherharshtreatmentofhimherefusestokillher.Eventually,whenMrs.LiftdrivesOwentothebreakingpoint,Larryfinallyrelentsandagreestogothroughwiththemurder.　　Aftertwounsuccessfulattempts,LarryfleestheLifthomewhenMrs.Liftrecognizeshimasasuspectfromanewsbroadcastabouthisex-wife'sdisappearance.HeboardsatraintoMexicoand,surprisingly,OwenandMrs.Liftcomealongsoastoavoidhavingtolieforhim.Duringthejourney,Larry'spatiencewithMrs.Liftreachesitspinnaclewhensheimpolitelygiveshimadviceonwriting.Hefollowshertothecaboosewiththeintentofthrowingherfromthetrain,butstopsshortwhenshealmostfallsoffonherown.OwenbeginshavingsecondthoughtsabouthavinghismotherkilledandcomestohelpLarryrescueher.Mrs.Liftisgratefulathersonforsavingher,butunappreciativeofLarry'shelpandkickshim,resultinginhimlosinghisbalance,landingonthetracks,andbreakinghisleg.　　Duringhisrecoveryinthehospital,LarrydiscoversMargaretisstillalive;shesimplyfelloverboardbyaccidentandwasrescuedbyaPolynesianfishermanwhomshehasdecidedtomarry.Muchtohisannoyance,LarrylearnsMargaretplanstoselltherightsofherordealfor$1.5milliondollars.Ontheadviceofafellowpatient,Larrychoosestofreehimselfofhisobsessionwithhisex-wifeandinsteadfocusonhisownlife,therebyfreeinghimofhiswriter'sblock.　　Ayearlater,LarryhasfinishedanovelbasedonhisexperienceswithOwenandMrs.LiftentitledThrowMommafromtheTrain.Owenvisitsandinformshimthathismotherhasdied(ofnaturalcauses)andthathe'sgoingtoNewYorkCityforthereleaseofhisownbook.Unfortunately,Owenrevealshisbookisalsoabouttheirexperiencestogether.Thinkinghisbookhasbeenscooped,anenragedLarryproceedstostranglehim,butstopswhenOwenshowshimthebookisachildren'spop-upbookcalled,Momma,Owen,andOwen'sFriendLarrywiththestorydrasticallyalteredtobesuitableforchildren.Monthslater,Larry,Owen,andLarry'sgirlfriendBeth(KimGreist)vacationtogetherinHawaii,reflectingonthefinalchapterofLarry'sbook.LarryandOwen'sbookshavenowbecomebest-sellers,makingthembothsuccessfulwritersaswellasclosefriends.